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How to use collagen, hyaluronic acid and retinol in your skincare routine

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Hyaluronic acid, retinol and collagen are often celebrated separately. But are they safe to use together? We shed light on this glow-getting trio

Summary

1What is hyaluronic acid?

Hyaluronic acid is celebrated for its skin hydrating properties. It's naturally present in our skin, connective tissue and eyes.

2Can you use them together?

Using hyaluronic acid, retinol and collagen together is considered safe and shouldn’t cause any adverse side effects.

3Top tips for use

Perform a patch test at least 24 hours before using any new hyaluronic acid or retinol product for the first time.

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Hyaluronic acid, retinol, collagen. They’re the superhero squad of skincare, so why not use them all and stack the benefits? But it can be tricky to know which products work well together – you want to make sure you’re not wasting your money. Fortunately, this trio can be used safely together and may even help each other out. It just comes down to understanding their individual benefits and how to use them in your routine. Let’s dive in...

What is hyaluronic acid?

Don’t let 'acid' scare you: hyaluronic acid is celebrated for its skin hydrating properties.1 You can get hyaluronic acid in supplements, but here we’re talking about its more popular topical form (in like serums and lotions). It's naturally present in our skin, connective tissue and eyes, but our levels decrease as we get older and make skin more prone to wrinkling and thinning.2 Adding hyaluronic acid, whether that's in a serum or face cream, into your skincare routine can help replenish the moisture levels in our skin. There's some evidence to suggest that, over time, it may help improve overall skin appearance too.3,4
Q+A Hyaluronic Facial Serum 30ml

Q+A

£6.95

£23.17/100 ml

What is retinol?

Retinol is a form of vitamin A, used in topical skincare for its potential in improving skin texture and evening out skin tone.5,6 That could be ideal if you’re looking to help smooth out rough skin and fine lines or make pigmented patches less noticeable. It’s pretty potent and should be used sparingly, so always follow the instructions on the packaging. It’s also important to use SPF daily, as retinol can make your skin more sensitive to UV – even on cloudy days.
Super Facialist Retinol Resurfacing Concentrate 30ml

Super Facialist

£20.00

£6.67/10 ml

What is collagen?

Collagen is a protein found in almost every part of our body and its job is to provide structural support to your tissues, skin, hair and nails.7 In our skin, this means helping to maintain firmness and elasticity.8 Collagen’s most popularly found in supplements such as powders, capsules or gummies.
Q+A Collagen Face Cream 50g

Q+A

£12.50

£25.00/100 g

Can you use hyaluronic acid with retinol and collagen?

Using hyaluronic acid, retinol and collagen together is considered safe and shouldn’t cause any adverse side effects. These skincare ingredients are commonly used together and are generally considered compatible. In fact, many skincare products already combine them in the same formulation, as they may complement each other in different ways.

Prefer to do your whole skincare routine in one go? Make sure it’s in the evening, as retinol increases the skin’s sensitivity to sunlight and so should only ever be applied at night.9 So, your routine might look like:
  • Hyaluronic acid (moisturisers/serums): can use morning and evening
  • Retinol: typically recommended for evening use
  • Collagen: any time of day
Though these ingredients are often used as a trio, it’s worth noting that there’s limited direct evidence specifically studying hyaluronic acid, retinol and collagen together as a three-ingredient combination.

Using hyaluronic acid, retinol and collagen: top tips

Hyaluronic acid can be used alongside retinol to help maintain hydration, while collagen can be included as part of your wider routine. Ready to start your new trio? Here’s how...
  • Perform a patch test at least 24 hours before using any new hyaluronic acid or retinol product for the first time
  • It's typically recommended to only apply retinol in the evening, as it increases the skin’s sensitivity to UV rays9
  • If you’re new to retinol, start by using it once or twice a week and build up slowly
  • Use a moisturiser as the last step in your skincare routine to help ‘lock’ in moisture
  • Using these ingredients regularly (but not too often) is more effective than overusing them all at once

Hyaluronic acid, retinol and collagen FAQs

Are hyaluronic acid, retinol and collagen vegan?

Both retinol and hyaluronic acid naturally come from animal sources but can be made synthetically so that they’re vegan. Even so, check individual products as they may contain other non-vegan ingredients. ‘True’ collagen comes from animals and so can never be vegetarian or vegan. However, you can find vegan collagen support (which contains amino acids to mimic the body’s natural collagen) as an alternative.
 

What shouldn't you use retinol with?

You shouldn’t mix retinol with strong exfoliators or acids like AHAs and BHAs, as this can over-exfoliate your skin and make it more sensitive. You also shouldn’t use it if you’re pregnant or already have delicate skin.5,10,11 Speak to your doctor or dermatologist if you’re introducing new ingredients to your skincare and not sure if they're right for your skin.
 

Can you use hyaluronic acid, retinol and collagen every day?

Hyaluronic acid can usually be used daily, both morning and evening, as it helps keep skin hydrated. Retinol, however, should be introduced gradually and is typically used a few times a week in the evening, depending on your skin type and tolerance. Collagen products can generally be used daily, but it’s always best to follow the instructions on individual products.
 

The final say

As long as you’re using all three products as they’re intended (and with proper sun protection), retinol, hyaluronic acid and collagen can work well as a skincare trio. Together, they may support firmer and smoother skin – what's not to love? If you're still chasing the ultimate glow, discover our top retinol creams or learn whether diet can really play a role in skin health...
Disclaimer – This article provides informational advice and is not a substitute for medical care. Working with experts for accuracy, we take great care to ensure the information is up-to-date and relevant. However, you should always consult your GP or healthcare professional before using supplements or alternative products, particularly if you have medical conditions or are under supervision.

Sources

1. European Commission. CosIng – Cosmetics Ingredients [Internet]. European Commission [cited 2026 May 11]. Available from: https://ec.europa.eu/growth/tools-databases/cosing/details/34315
2. Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol [Internet]. 2012 Jul 1 [cited 2026 May 11]; 4(3): 253-8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886/
3. Bukhari SNA, et al. Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. Int J Biol Macromol. 2018;120(Pt B):1682–95. https://doi.org/10.1016/j.ijbiomac.2018.09.188
4. Jegasothy SM, et al. Efficacy of a new topical nano-hyaluronic acid in humans. J Clin Aesthet Dermatol. 2014;7(3):27–9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970829
5. Milosheska D, Roškar R. Use of retinoids in topical antiaging treatments: A focused review of clinical evidence for conventional and nanoformulations. Adv Ther. 2022;39:5351–75. https://doi.org/10.1007/s12325-022-02319-7
6. Spierings NMK. Evidence for the efficacy of over-the-counter vitamin a cosmetic products in the improvement of facial skin aging: A systematic review. J Clin Aesthet Dermatol. 2021;14(9):33–40. https://pmc.ncbi.nlm.nih.gov/articles/PMC8675340/
7. Wu M, et al. Biochemistry, collagen synthesis. StatPearls Publishing; 2023. https://www.ncbi.nlm.nih.gov/books/NBK507709
8. Dierckx S et al. Collagen peptides affect collagen synthesis and the expression of collagen, elastin, and versican genes in cultured human dermal fibroblasts. Dermatology [Internet]. 2024 [cited 2026 May 11]; 11. Available from: https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1397517/full9. National Institute for Health and Care Excellence (NICE). Topical retinoids [Internet]. NICE [reviewed 2026 Feb; cited 2026 May 11]. Available from: https://cks.nice.org.uk/topics/acne-vulgaris/prescribing-information/topical-retinoids/
10. American Academy of Dermatology Association. Retinoid or retinol? [Internet]. [cited 2025 Jan 23]. Available from: https://www.aad.org/public/everyday-care/skin-care-secrets/anti-aging/retinoid-retinol
11. Putra IB, et al. Skin changes and safety profile of topical products during pregnancy. J Clin Aesthet Dermatol. 2022;15(2):49–57. https://pmc.ncbi.nlm.nih.gov/articles/PMC8884185/
 
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